FURAN FATTY-ACID STERYL ESTERS FROM THE MARINE SPONGE DICTYONELLA-INCISA WHICH SHOW INFLAMMATORY ACTIVITY

被引：38

作者：

CIMINIELLO, P ^{[1
]}

FATTORUSSO, E ^{[1
]}

MAGNO, S ^{[1
]}

MANGONI, A ^{[1
]}

IALENTI, A ^{[1
]}

DIROSA, M ^{[1
]}

机构：

[1] DIPARTIMENTO FARMACOL SPERIMENTALE,I-80131 NAPLES,ITALY

来源：

EXPERIENTIA | 1991年 / 47卷 / 07期

关键词：

DICTYONELLA-INCISA; FURAN FATTY ACIDS; INFLAMMATORY ACTIVITY; BY HISTAMINE RELEASE;

D O I：

10.1007/BF01958832

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three new furan fatty acids, (9Z,19Z)-3, 6-epoxyhexacosa-3,5,9,19-tetraenoic acid (1a), (8Z,11Z,14Z,17Z)-3, 6-epoxyeicosa-3,5,8,11,14,17-hexaenoic acid (2a), and (8Z,11Z,14Z,17E)-3, 6-epoxyeicosa-3,5,8,11,14,17-hexaenoic (3a), and a new polyunsaturated fatty acid (5Z,8Z,11Z,14Z,17E)-eicosa-5,8,11,14,17-pentaenoic acid (6a), present in the sponge Dictyonella incisa as the respective steryl esters, have been isolated as methyl esters and their structures have been determined by spectral and chemical analysis. The furan fatty acid esters have shown a high inflammatory activity, which suggests their potential role as feeding deterrents.

引用

页码：739 / 743

页数：5

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