TRANSFORMING GROWTH-FACTOR-BETA ENHANCES FRACTURE-HEALING IN RABBIT TIBIAE

被引：182

作者：

LIND, M

SCHUMACKER, B

SOBALLE, K

KELLER, J

MELSEN, F

BUNGER, C

机构：

[1] AARHUS UNIV,INST EXPTL CLIN RES,DK-8000 AARHUS,DENMARK

[2] AARHUS UNIV,ORTHOPED RES UNIT,DK-8000 AARHUS,DENMARK

[3] AARHUS UNIV,INST PATHOL,DK-8000 AARHUS,DENMARK

来源：

ACTA ORTHOPAEDICA SCANDINAVICA | 1993年 / 64卷 / 05期

关键词：

D O I：

10.3109/17453679308993691

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The ability of exogenous Transforming Growth Factor-beta (TGF-beta) to stimulate bone formation in fracture healing was investigated. TGF-beta was continuously applied in doses of 1 and 1 0 mug/day for 6 weeks to 2 groups of adult rabbits with unilateral plated midtibial osteotomies. A group receiving solvent without TGF-beta served as control. Fracture healing was evaluated by mechanical tests, bone morphometry and bone densitometry. Increased maximal bending strength and callus formation were demonstrated in the groups receiving TGF-beta. TGF-beta had no effect on bending-stiffness, bone mineral content, cortical thickness or haversian canal diameter. We conclude that local application of exogenous TGF-beta may enhance fracture healing in rabbits.

引用

页码：553 / 556

页数：4

共 14 条

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