REACTIVATION OF CHRONIC HEPATITIS-C AFTER WITHDRAWAL OF IMMUNOSUPPRESSIVE THERAPY

被引：40

作者：

GRUBER, A

LUNDBERG, LG

BJORKHOLM, M

机构：

[1] Department of Internal Medicine, Section of Haematology and Immunology, Karolisnka Hospital, Stockholm

来源：

JOURNAL OF INTERNAL MEDICINE | 1993年 / 234卷 / 02期

关键词：

CHRONIC; HEPATITIS-C; IMMUNOSUPPRESSION;

D O I：

10.1111/j.1365-2796.1993.tb00734.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with immune-mediated thrombocytopenia (ITP) and chronic hepatitis C virus (HCV) infection for 11 years was given immunosuppressive treatment because of an activation of his ITP. After 6 weeks of treatment with cyclophosphamide, cyclosporin A and cortisone the patient decided not to continue taking his medication. One month later he was readmitted to hospital due to fever, cough and jaundice. Clinical investigation revealed his condition to be caused by an activation of his HCV infection. It is concluded that, in parallel to the situation in hepatitis B, immunosuppressive treatment of patients with HCV infection may lead to increased viral replication, resulting in severe liver damage when immunocompetence is regained.

引用

页码：223 / 225

页数：3

共 14 条

[1]

DIENSTAG JL, 1986, CLIN APPROACH INFECT, P325

[2]

FAN FS, 1991, BONE MARROW TRANSPL, V8, P417

[3] DEMONSTRATION OF VIREMIA PATTERNS IN HEMOPHILIACS TREATED WITH HEPATITIS-C-VIRUS-CONTAMINATED FACTOR-VIII CONCENTRATES [J].