ASYMMETRIC-SYNTHESIS OF IBUPROFEN AND KETOPROFEN

被引：12

作者：

HAMON, DPG

MASSYWESTROPP, RA

NEWTON, JL

机构：

[1] Department of Organic Chemistry, University of Adelaide, Adelaide, SA 5001

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(00)80334-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(S)-2-[4'-(2''-Methylpropyl)phenyl]propanoic acid (ibuprofen) and (S)-2-(3'-benzoylphenyl)propanoic acid (ketoprofen) have been synthesis in high enantiomeric excess. Control of the stereochemistry was achieved by a combination of Sharpless epoxidation followed by catalytic hydrogenolysis of the introduced benzylic epoxide oxygen bond.

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页码：1435 / 1438

页数：4

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