THE CELLULAR-RESPONSES TO DNA-DAMAGE

被引：108

作者：

CARR, AM ^{[1
]}

HOEKSTRA, MF ^{[1
]}

机构：

[1] ICOS CORP,BOTHELL,WA 98021

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0962-8924(00)88934-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ability to survive spontaneous and induced DNA damage, and to minimize the number of heritable mutations that this causes, is essential to the maintenance of genome integrity for all organisms. Early studies on model eukaryotes focused on genes acting in defined DNA repair pathways. More recent work with the budding and fission yeasts and mammalian cells has started to integrate the DNA damage response with cell physiology and the cell cycle.

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页码：32 / 40

页数：9

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