NUCLEAR RIBONUCLEOPROTEINS RECOGNIZED BY HUMAN ANTI-NUCLEAR ANTIBODIES IN RETROVIRUS-INFECTED CELLS

被引：23

作者：

BARQUE, JP

YENI, P

PERAUDEAU, L

DANON, F

LARSEN, CJ

机构：

[1] HOP ST LOUIS, PHARMACOL EXPTL LAB, F-75475 PARIS 10, FRANCE

[2] HOP ST LOUIS, IMMUNOCHIM IMMUNOPATHOL LAB, U108, F-75475 PARIS 10, FRANCE

[3] HOP ST LOUIS, CNRS, ONCOL & IMMUNOL LAB, F-75475 PARIS 10, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1981年 / 99卷 / 01期

关键词：

D O I：

10.1016/0006-291X(81)91743-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibodies present in sera of patients with autoimmune diseases (systemic lupus erythematosus, mixed connective tissue disease) were reacted with nuclear ribonucleoproteins from normal cells and cells infected with retroviruses. Only antibodies directed against Sm and RNP [ribonucleoprotein] antigens precipitated particles with the definite spectra of small nuclear RNA and proteins. No difference was found between infected and uninfected cells, suggesting that virus replication is dependent on normal cellular functions.

引用

页码：284 / 291

页数：8

共 14 条

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