NEUROLEPTIC ACTION OF QUATERNARY CHLORPROMAZINE AND RELATED DRUGS INJECTED INTO VARIOUS BRAIN AREAS IN RATS

被引：67

作者：

FOG, RL

RANDRUP, A

PAKKENBERG, H

机构：

[1] Dept. E, Roskilde, and Kommunehospitalet Laboratory of Neuropathology, St. Hans Hospital, Copenhagen

来源：

PSYCHOPHARMACOLOGIA | 1968年 / 12卷 / 05期

关键词：

Amphetamine; Chlorpromazine; Dopamine; Ganglia; Basal; Psychopharmacology;

D O I：

10.1007/BF00401348

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

In rats micro-injections in corpus striatum of quaternary chlorpromazine and related drugs give rise to highly characteristic neuroleptic effects: antagonism of amphetamine-induced stereotyped behaviour and development of catalepsy. There is no effect of injections in hippocampus or septum. Dopaminergic mechanisms in corpus striatum seem to play a central role in neuroleptic action. © 1968 Springer-Verlag.

引用

页码：428 / +

页数：1

共 17 条

[1] EFFECTS OF CHLORPROMAZINE, HALOPERIDOL AND RESERPINE ON THE LEVELS OF PHENOLIC ACIDS IN RABBIT CORPUS STRIATUM [J].

ANDEN, NE ;

ROOS, BE ;

WERDINIUS, B .

LIFE SCIENCES, 1964, 3 (02) :149-158

[2]

ANDEN NE, 1966, ACTA PHARMACOL TOX, V24, P263

[3]

COSTA E, BIOCHEMISTRY PHAR ED, P123

[4]

DAPRADA M, 1966, J PHARM PHARMACOL, V18, P628

[5]

FISHER AE, 1967, SCIENCE, V157, P839

[6] AMINERGIC MECHANISMS IN CORPUS STRIATUM AND AMPHETAMINE-INDUCED STEREOTYPED BEHAVIOUR [J].

FOG, RL ;

RANDRUP, A ;

PAKKENBE. .

PSYCHOPHARMACOLOGIA, 1967, 11 (02) :179-179

[7]

FOG RL, 1968, EXCERPTA MEDICA 150, P715

[8]

FUXE K, BIOCHEMISTRY PHARMAC, P123

[9]

JANSSEN C, 1965, DRUG RES ARZNEIMITTE, V15, P104

[10]

MUNKVAD I, 1966, ACTA PSYCHIAT SCAND, VS 42, P178

← 1 2 →