FACTORS INVOLVED IN SKIN CARCINOGENESIS

被引：9

作者：

PINKUS, H ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT DERMATOL & SYPHILOL,DETROIT,MI 48202

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1979年 / 1卷 / 03期

关键词：

D O I：

10.1016/S0190-9622(79)70020-X

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A personal account of skin carcinogenesis is given based on forty years of investigation of norma! and pathologic anatomy of the human skin. Symbiosis of acral portions of adnexa and of melanocytes with epidermal keratinocytes is stressed, and perversion of symbiosis to parasitism in tumor formation is discussed. The role of the basement membrane as a combined effort of, and filter between, ectoderm and mesoderm is stressed, and the nature of basal cell epithelioma as the least differentiated member of the tribe of fibroepithelial adnexal tumors is outlined. Experimental data supporting the promoting role of specific mesodermal stroma in basalioma formation and maintenance are presented. © 1979, All rights reserved.

引用

页码：267 / 275

页数：9

共 31 条

[1]

Freudenthal W, Verruca senilis und Keratoma senile, Arch Derm Syph (Berl), 152, pp. 505-528, (1926)

[2]

Pinkus H, Ueber einen Fall von Basalzellenepitheliom auf Verruca senilis, Arch Derm Syph (Berl), 169, pp. 58-66, (1933)

[3]

Pinkus H, Ueber Gewebekulturen menschlicher Epidermis. Ein Beitrag zur Anatomie der Haut, Arch Derm Syph (Berl), 165, pp. 53-85, (1932)

[4]

Liu S-C, Karasek M, Isolation and growth of adult human epidermal keratinocytes in cell culture, J Invest Dermatol, 71, pp. 157-162, (1978)

[5]

Pinkus H, The isolation of pure strains of cells from human tumors. II. Growth characteristics of a sarcoma and two brain tumors in tissue culture, The American Journal of Cancer, 29, pp. 25-46, (1937)

[6]

Pinkus H, Gould S, Extramammary Paget's disease and intraepidermal carcinoma, Archives of Dermatology, 39, pp. 479-502, (1939)

[7]

Pinkus H, Four-dimensional histopathology, Arch Dermatol, 82, pp. 681-689, (1960)

[8]

Pinkus H, The concept of symbiosis applied to normal and abnormal growth in the human epidermis, Dermatology, 117, pp. 369-379, (1958)

[9]

Silberberg-Sinakin I, Baer RL, Thorbekke GJ, Langerhans cells. A review of their nature with emphasis on their immunologic functions, Prog Allergy, 24, pp. 268-294, (1978)

[10]

Pinkus H, Biology of epidermal cells, Physiology and biochemistry of the skin, pp. 584-600, (1954)

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