PLASMINOGEN-ACTIVATOR INHIBITOR-1 RESPONSE TO A CARBOHYDRATE MEAL IN OBESE SUBJECTS

被引：13

作者：

MEDVESCEK, M ^{[1
]}

KEBER, D ^{[1
]}

STEGNAR, M ^{[1
]}

BOROVNICAR, A ^{[1
]}

机构：

[1] EDVARD KARDELJ UNIV, MED CTR, TRNOVO HOSP INTERNAL MED, YU-61000 LJUBLJANA, YUGOSLAVIA

来源：

FIBRINOLYSIS | 1990年 / 4卷

关键词：

Carbohydrate meal; Obesity; Plasminogen activator inhibitor;

D O I：

10.1016/0268-9499(90)90371-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The response of PAI-1 to a high-caloric carbohydrate meal was studied in two groups of healthy volunteers: 10 younger, lean and 11 middle-aged obese individuals. Both groups underwent a 4 hr morning observation period under two different conditions - with a carbohydrate load and fast. In both groups a significant meal-related peak in PAI activity occurred between 60 and 120 min, being of approximately the same magnitude in both groups. PAI antigen showed a plateau after the meal instead of a fall during fast. The obese group displayed much higher basal levels of PAI activity and also antigen, insulin and triglycerides, as well as insulin and glucose levels after the meal. © 1990.

引用

页码：89 / 90

页数：2