MODELING NEUTRAL AND SELECTIVE EVOLUTION OF PROTEIN FOLDING

被引：121

作者：

LIPMAN, DJ

WILBUR, WJ

机构：

[1] Nat. Center for Biotech. Info., National Library of Medicine, NIH, Building 38A, Bethesda

来源：

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1991年 / 245卷 / 1312期

关键词：

D O I：

10.1098/rspb.1991.0081

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examine a model evolutionary space consisting of genotypes mapped to their corresponding phenotypes. This mapping is derived from a lattice model for proteins which, despite its highly idealized nature, has been shown to share general properties with real proteins. Large evolutionary networks are observed, with genotypes corresponding to non-lethal phenotypes linked by unit mutational steps. Neutral mutations are necessary for traversing the evolutionary networks, and even one neutral mutation in a genotype can change the phenotypes attainable by a unit mutational step.

引用

页码：7 / 11

页数：5

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