RETINOIDS ENHANCE MITOGENESIS BY TUMOR PROMOTOR AND POLYPEPTIDE GROWTH-FACTORS

被引：53

作者：

DICKER, P

ROZENGURT, E

机构：

[1] Imperial Cancer Research Fund Lincoln's Inn Fields, London

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 91卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91195-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retinoids at low concentrations strikingly enhance the growth-promoting activity of polypeptides like epidermal growth factor, insulin, vasopressin and fibroblast-derived growth factor and of 12-0-tetradecanoyl-phorbol-13-acetate, a potent tumour-promoting agent. Retinoids enhance both DNA synthesis and cell proliferation in quiescent cultures of mouse 3T3 cells and of hamster Nil-8 cells. These findings contrast with previous reports showing growth inhibitory properties of retinoids. © 1979.

引用

页码：1203 / 1210

页数：8

共 21 条

[1] 18,000 MOLECULAR-WEIGHT POLYPEPTIDE INDUCES EARLY EVENTS AND STIMULATES DNA-SYNTHESIS IN CULTURED-CELLS
BOURNE, HR
ROZENGURT, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (12) : 4555 - 4559
[2] INHIBITION OF EPIDERMAL GROWTH-FACTOR BINDING TO SURFACE RECEPTORS BY TUMOR PROMOTORS
BROWN, KD
DICKER, P
ROZENGURT, E
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1979, 86 (04) : 1037 - 1043
[3] STIMULATION OF DNA-SYNTHESIS BY TUMOR PROMOTER AND PURE MITOGENIC FACTORS
DICKER, P
ROZENGURT, E
[J]. NATURE, 1978, 276 (5689) : 723 - 726
[4] VITAMIN-A-INDUCED DENSITY-DEPENDENT INHIBITION OF L-CELL PROLIFERATION
DION, LD
BLALOCK, JE
GIFFORD, GE
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 58 (03) : 795 - 801
[5] GLOVER J, 1947, BIOCHEM J, V41, P95
[6] HEILMAN C, 1975, FED PROC, V34, P822
[7] CHARACTERIZATION OF THE ACTION OF RETINOIDS ON MOUSE FIBROBLAST CELL-LINES
JETTEN, AM
JETTEN, MER
SHAPIRO, SS
POON, JP
[J]. EXPERIMENTAL CELL RESEARCH, 1979, 119 (02) : 289 - 299
[8] KENSLER TW, 1978, CANCER RES, V38, P771
[9] INHIBITORY EFFECTS OF RETINOIC ACID OR RETINYL ACETATE ON GROWTH OF UNTRANSFORMED, TRANSFORMED, AND TUMOR-CELLS INVITRO
LOTAN, R
NICOLSON, GL
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (06) : 1717 - 1722
[10] RETINOIDS, A NEW CLASS OF COMPOUNDS WITH PROPHYLACTIC AND THERAPEUTIC ACTIVITIES IN ONCOLOGY AND DERMATOLOGY
MAYER, H
BOLLAG, W
HANNI, R
RUEGG, R
[J]. EXPERIENTIA, 1978, 34 (09): : 1105 - 1119

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