ALTERATIONS IN MYOCARDIAL ADENYLATE-CYCLASE IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：18

作者：

PALMER, GC ^{[1
]}

GREENBERG, S ^{[1
]}

机构：

[1] UNIV S ALABAMA, COLL MED, DEPT PHARMACOL, MOBILE, AL 36688 USA

来源：

PHARMACOLOGY | 1979年 / 19卷 / 03期

关键词：

D O I：

10.1159/000137303

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Particulate fractions of myocardium taken from spontaneously hypertensive rats (SHR) contained an adenylate cyclase system that was less responsive than normotensive Wistar Kyoto rats to norepinephrine [NE], isoproterenol (mixed .beta.-agonist), salbutamol (.beta.2-agonist), dobutamine (.beta.1-agonist), dopamine, histamine and glucagon. Addition of 5''-guanylylimidodiphosphate to the SHR myocardial preparation again yielded a lessened sensitivity to all agents except NE, dopamine and histamine. Chronic treatment of SHR with clonidine and a high dose of propranolol produced a cardiac enzyme that was insensitive to activation by NE. Similar treatment with a low dose of propranolol did not alter myocardial responses to NE.

引用

页码：156 / 162

页数：7

共 29 条

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