TRH ATTENUATES SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT IN HUMANS

被引:72
作者
MOLCHAN, SE
MELLOW, AM
LAWLOR, BA
WEINGARTNER, HJ
COHEN, RM
COHEN, MR
SUNDERLAND, T
机构
[1] UNIV S CAROLINA,SCH MED,WILLIAM S HALL PSYCHIAT INST,ENSOR RES LAB,COLUMBIA,SC 29202
[2] UNIV MICHIGAN,MED CTR,DEPT PSYCHIAT,ANN ARBOR,MI 48104
[3] GEORGE WASHINGTON UNIV,DEPT PSYCHOL,WASHINGTON,DC 20036
[4] NIMH,CEREBRAL METAB LAB,CLIN BRAIN IMAGING SECT,BETHESDA,MD 20892
关键词
Memory; Neuropeptide; Scopolamine; Thyrotropin-releasing hormone (TRH);
D O I
10.1007/BF02245795
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5-0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes. © 1990 Springer-Verlag.
引用
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页码:84 / 89
页数:6
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