INDUCTION OF SISTER CHROMATID EXCHANGES BY NICOTINAMIDE IN CHINESE-HAMSTER LUNG FIBROBLASTS AND HUMAN-LYMPHOBLASTOID CELLS

被引：43

作者：

UTAKOJI, T

HOSODA, K

UMEZAWA, K

SAWAMURA, M

MATSUSHIMA, T

MIWA, M

SUGIMURA, T

机构：

[1] UNIV TOKYO,INST MED SCI,MINATO KU,TOKYO 113,JAPAN

[2] NATL CANC CTR,RES INST,CHUO KU,TOKYO 104,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)91156-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nicotinamide, which occurs naturally, produced sister chromatid exchanges in Chinese hamster lung fibroblasts and human lymphoblastoid cells. The inductions were dose-dependent with concentrations of 1.0-10.0 mM nicotinamide. Elastatinal, a protease inhibitor that has been reported to suppress induction of sister chromatid exchanges by N-methyl-N′-nitro-N-nitrosoguanidine, did not suppress induction of sister chromatid exchanges by nicotinamide in these cell lines. © 1979.

引用

收藏

页码：1147 / 1152

页数：6

相关论文

共 27 条

[1] BIOLOGICAL METHYLATION - SELECTED ASPECTS [J].

CANTONI, GL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1975, 44 :435-451

[2] ON FORMATION OF A NOVEL ADENYLIC COMPOUND BY ENZYMATIC EXTRACTS OF LIVER NUCLEI [J].

CHAMBON, P ;

WEILL, JD ;

DOLY, J ;

STROSSER, MT ;

MANDEL, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1966, 25 (06) :638-&

[3] AMINO ACID METABOLISM IN MAMMALIAN CELL CULTURES [J].

EAGLE, H .

SCIENCE, 1959, 130 (3373) :432-437

[4]

Evans, 1976, CHEMICAL MUTAGENS PR, P1, DOI 10.1007/978-1-4684-0892-8_1

[5] POLYMERIZATION OF ADENOSINE 5'-DIPHOSPHATE-RIBOSE MOIETY OF NICOTINAMIDE-ADENINE DINUCLEOTIDE BY NUCLEAR ENZYME .I. ENZYMATIC REACTIONS [J].

FUJIMURA, S ;

HASEGAWA, S ;

SHIMIZU, Y ;

SUGIMURA, T .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 145 (02) :247-&

[6] NICOTINAMIDE - NATURAL INHIBITOR OF TRANSFER RNA METHYLASE [J].

HALPERN, RM ;

CHANEY, SQ ;

HALPERN, BC ;

SMITH, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1971, 42 (04) :602-&

[7] POLY(ADP-RIBOSE) AND ADP-RIBOSYLATION OF PROTEINS [J].

HAYAISHI, O ;

UEDA, K .

ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :95-116

[8] POLY(ADP-RIBOSE) AND ADP-RIBOSYLATION OF PROTEINS [J].

HILZ, H ;

STONE, P .

REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, 1976, 76 :1-58

[9]

Kato H., 1977, International Rev Cytol, V49, P55

[10] TUMOR PROMOTER INDUCES SISTER CHROMATID EXCHANGES - RELEVANCE TO MECHANISMS OF CARCINOGENESIS [J].

KINSELLA, AR ;

RADMAN, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (12) :6149-6153