BLOOD HYPERVISCOSITY AND ITS RELATIONSHIP TO PROGRESSIVE RENAL-FAILURE IN PATIENTS WITH DIABETIC NEPHROPATHY

被引：17

作者：

GORDGE, MP ^{[1
]}

PATEL, A ^{[1
]}

FAINT, RW ^{[1
]}

RYLANCE, PB ^{[1
]}

NEILD, GH ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,UNIV COLL & MIDDLESEX SCH MED,INST UROL,DEPT RENAL MED,LONDON WC1E 6BT,ENGLAND

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 10期

关键词：

Blood viscosity; Diabetic nephropathy; Fibrinogen; Proteinuria;

D O I：

10.1111/j.1464-5491.1990.tb01323.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood rheology was investigated in patients with diabetic nephropathy and progressive renal insufficiency, and compared with similar non‐diabetic patients and healthy control subjects. Plasma viscosity and whole blood viscosity at standardized haematocrit were elevated to a comparable degree in the two patient groups, but erythrocyte deformability was normal. In diabetic patients, the rate of progression of renal failure showed weak, but significant, correlations with plasma viscosity (rs = 0.50, p = 0.005), standardized whole blood viscosity (rs = 0.41, p = 0.021), plasma fibrinogen (rs = 0.46, p = 0.010), C reactive protein (rs = 0.40, p = 0.023), and proteinuria (rs = 0.52, p = 0.003). Both plasma viscosity and plasma fibrinogen correlated significantly with proteinuria (rs = 0.45, p = 0.012 and 0.40, p = 0.027, respectively). Rheological abnormality is probably a manifestation of increased acute phase proteins, but it remains to be determined whether these are the cause or the effect of the renal injury. Abnormal blood rheology may be a risk factor for the progression of renal failure in diabetic nephropathy. 1990 Diabetes UK

引用

页码：880 / 886

页数：7

共 31 条

[1]

Parving H., Andersen AR, Smidt UM, Hommel E., Mathiesen ER, Svendsen PA, Effect of antihypertensive treatment on kidney function in diabetic nephropathy, Br Med J, 294, pp. 1443-1452, (1987)

[2]

Viberti GC, Bilous RW, Mackintosh D., Bending JJ, Keen H., Long‐term correction of hyperglycaemia and progression of renal failure in insulin dependent diabetes, Br Med J, 286, pp. 598-602, (1983)

[3]

Diamond JR, Karnovsky MJ, Focal and segmental glomerulosclerosis: analogies to atherosclerosis, Kidney Int, 33, pp. 917-924, (1988)

[4]

Farquhar A., MacDonald MK, Ireland JT, The role of fibrin deposition in diabetic glomerulosclerosis: a light, electron and immunofluorescence study, J Clin Pathol, 25, pp. 657-667, (1972)

[5]

Small M., Lowe GDO, MacCuish AC, Forbes CD, Thrombin and plasmin activity in diabetes mellitus and their association with glycaemic control, Q J Med, 65, pp. 1025-1031, (1987)

[6]

Colwell JA, Halushka PV, Platelet function in diabetes mellitus, Br J Haematol, 44, pp. 521-526, (1980)

[7]

Haitas B., Barnes AJ, Cederholm-Williams SA, Moore J., Shogry MEC, Turner RC, Abnormal endothelial release of fibrinolytic activity and fibronectin in diabetic microangiopathy, Diabetologia, 27, pp. 493-496, (1984)

[8]

Lowe GDO, Blood rheology in arterial disease, Clin Sci, 71, pp. 137-146, (1986)

[9]

McMillan DE, Utterback NG, Stocki J., Low shear rate blood viscosity in diabetes, Biorheology, 17, pp. 355-362, (1980)

[10]

McMillan DE, The effects of diabetes on blood flow properties, Diabetes, 32, pp. 56-63, (1983)

← 1 2 3 4 →