CHANGE IN TRANSFER RATE OF METHOTREXATE FROM SPINAL-FLUID TO PLASMA DURING INTRATHECAL THERAPY IN CHILDREN AND ADULTS

被引：21

作者：

LANKELMA, J

LIPPENS, RJJ

DRENTHESCHONK, A

TERMOND, EFS

VANDERKLEIJN, E

机构：

[1] ST RADBOUD HOSP,DEPT CLIN PHARMACOL,NIJMEGEN,NETHERLANDS

[2] ST RADBOUD HOSP,DEPT PAEDIAT,NIJMEGEN,NETHERLANDS

[3] ST RADBOUD HOSP,DEPT INTERNAL MED,DIV HAEMATOL,NIJMEGEN,NETHERLANDS

来源：

CLINICAL PHARMACOKINETICS | 1980年 / 5卷 / 05期

关键词：

D O I：

10.2165/00003088-198005050-00004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：465 / 475

页数：11

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[2]

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[6]

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[7] TREATMENT OF LEUKEMIA WITH LARGE DOSES OF METHOTREXATE AND FOLINIC ACID - CLINICAL-BIOCHEMICAL CORRELATES [J].

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BERTINO, JR .

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[8]

HUFFMAN DH, 1973, CLIN PHARMACOL THER, V14, P572

[9] DETERMINATION OF METHOTREXATE IN PLASMA BY ON-COLUMN CONCENTRATION AND ION-EXCHANGE CHROMATOGRAPHY [J].

LANKELMA, J ;

POPPE, H .

JOURNAL OF CHROMATOGRAPHY, 1978, 149 (FEB) :587-598

[10] A METHOD FOR MINIMIZING A SUM OF SQUARES OF NON-LINEAR FUNCTIONS WITHOUT CALCULATING DERIVATIVES [J].

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