SYNTHESIS OF GLYCOCONJUGATES BY COVALENT COUPLING OF O-GLYCOPYRANOSYL-N-HYDROXYSUCCINIMIDE DERIVATIVES OF LACTOSE TO PROTEINS AND LIPIDS AND POLYMERIZATION OF THEIR PARENT ACRYLOYL DERIVATIVES INTO ACRYLAMIDE POLYMERS

Glycosides of N-hydroxysuccinimide have been synthesized and the succinimide moieties have been opened by amines to give glycolipids or spacer-glycosides. The latter have been coupled to proteins and, after acryloylation, copolymerized into acrylamide polymers. A C-13-NMR study of the stability of the anomeric O-N-C(O) linkage showed the linkage to be stable under conditions used in most biological experiments.