MECHANISMS OF HEAVY-METAL CATION HOMEOSTASIS IN MARINE-INVERTEBRATES

被引：448

作者：

VIARENGO, A ^{[1
]}

NOTT, JA ^{[1
]}

机构：

[1] PLYMOUTH MARINE LAB,PLYMOUTH,ENGLAND

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1993年 / 104卷 / 03期

关键词：

D O I：

10.1016/0742-8413(93)90001-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The main mechanisms involved in heavy metal cation homeostasis in marine invertebrate cells are described. 2. Metallothioneins are probably the most important soluble compounds involved in heavy metal cation homeostasis. The biochemical characteristics of these metalloproteins and the relationship between their amino acid composition and heavy metal binding capacity are elucidated. Moreover data are reported concerning the physiological role of metallothioneins e.g. heavy metal detoxification, cellular metal redistribution, free radical scavenger action, etc. The possible meaning of different soluble compounds in heavy metal cation homeostasis is also discussed. 3. The biochemical role of lysosomes in heavy metal cation compartmentalization and the involvement of these organelles in metallothionein accumulation and sequestration are shown. 4. Data are reported concerning the sequestration of heavy metal cations in insoluble granules as a mechanism of metal detoxification.

引用

页码：355 / 372

页数：18

共 202 条

[1] FUNCTIONAL CYTOLOGY OF THE HEPATOPANCREAS OF PENAEUS-SEMISULCATUS (CRUSTACEA, DECAPODA) DURING THE MOLT CYCLE [J].