COMPARATIVE-STUDY OF THE INTERACTIONS OF CISPLATIN AND CARBOPLATIN WITH NUCLEOTIDES USING UV RESONANCE RAMAN-SPECTROSCOPY

被引：3

作者：

BENSON, RL ^{[1
]}

GUSTAFSON, TL ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT CHEM,120 W 18TH AVE,COLUMBUS,OH 43210

来源：

BIOPOLYMERS | 1993年 / 33卷 / 11期

关键词：

D O I：

10.1002/bip.360331102

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have obtained the UV excited resonance Raman spectra of five mononucleotides bound to cisplatin and to carboplatin using excitation in resonance with the first electronic absorption bands of the nucleotide bases. Substantial changes in the spectra are observed. following interaction with both platinum drugs, indicating modifications to nucleotide structure. Pt (II) binds to base portions of the nucleotide molecules, altering their normal modes of vibration significantly. We present comparative data of cisplatin and carboplatin, and discuss the implications of these results. The kinetics of the drug/nucleotide reactions differ, but final products are found to be similar. (C) 1993 John Wiley & Sons, Inc.

引用

页码：1631 / 1641

页数：11

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