MODELING REPRODUCTIVE TOXICITY IN CERIODAPHNIA TESTS

被引：34

作者：

BAILER, AJ ^{[1
]}

ORIS, JT ^{[1
]}

机构：

[1] MIAMI UNIV, DEPT ZOOL, OXFORD, OH 45056 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 1993年 / 12卷 / 04期

关键词：

GENERALIZED LINEAR MODELS; POISSON REGRESSION; POTENCY ESTIMATION;

D O I：

10.1002/etc.5620120421

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A model for Ceriodaphnia dubia reproductive toxicity outcomes is presented. This model assumes that the number of young is a Poisson-distributed random variable and that the mean number of young can be modeled using an exponential term involving a polynomial in the test concentrations. Given these assumptions, a modeling procedure for reproductive outcomes is developed and is used to derive an estimate of potency of the chemical under test. Confidence intervals for this estimate are obtained using a bootstrap resampling procedure.

引用

页码：787 / 791

页数：5

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