CELL-CULTURE AS A TOOL FOR IDENTIFYING NUTRITIONAL DISEASE THERAPIES

被引：4

作者：

BALLARD, FJ

机构：

来源：

JOURNAL OF NUTRITION | 1994年 / 124卷 / 08期

关键词：

INSULIN-LIKE GROWTH FACTOR; IGF VARIANTS; POLYTRAUMA; CULTURED MUSCLE CELLS; IGF-BINDING PROTEINS;

D O I：

10.1093/jn/124.suppl_8.1540S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cell culture methodologies can be used to help develop therapies for the treatment of polytrauma. An overview is presented of research with the L6 myoblast cell line that led to the discovery of the truncated insulin-like growth factor (IGF) variant, des(1-3)IGF-I and that gave an explanation of the enhanced potency of this growth factor. Subsequent efforts to develop an even more potent variant also utilized cultured cells as indicator bioassays. Such experiments not only provided mechanistic information on IGF action but also directed attention towards IGF variants that were later shown to be more potent in vivo at reversing catabolic conditions

引用

收藏

页码：S1540 / S1545

页数：6

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