POTENTIOMETRIC MICROTITRATION OF VITAMIN-B-1 WITH PHOSPHOTUNGSTIC ACID BY USING A PHOSPHOTUNGSTATE-SENSITIVE ELECTRODE AND ITS APPLICATION TO THE ANALYSIS OF PHARMACEUTICAL PREPARATIONS

被引:10
作者
CAMPIGLIO, A
机构
关键词
VITAMIN-B-1; POTENTIOMETRIC TITRATION; PHOSPHOTUNGSTATE-SENSITIVE ELECTRODE; PHOSPHOTUNGSTIC ACID; PHARMACEUTICAL PREPARATION;
D O I
10.1039/an9941902209
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method for the determination of micro-amounts of vitamin B-1 by direct potentiometric titration in aqueous medium with a standard phosphotungstic acid solution is described. A graphite electrode coated with a PVC matrix membrane containing the benzyldimethyltetradecylammonium-phosphotungstate ion association complex as electroactive material and dioctyl phthalate as plasticizer war constructed and used in conjunction with a Ag-AgCl double-junction reference electrode to detect the end-point of the titration; This method gave very satisfactory results in the range 1-4 mg of vitamin B-1, also in comparison with other methods; the recoveries were 100.00 +/- 0.25% and the mean relative standard deviation was 0.22%. The method was successfully applied to the analysis of pharmaceutical preparations.
引用
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页码:2209 / 2212
页数:4
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