PARALLEL COMPUTATION OF GENETIC LIKELIHOODS USING CRI-MAP, PVM, AND A NETWORK OF DISTRIBUTED WORKSTATIONS

被引：9

作者：

MATISE, TC

SHROEDER, MD

CHIARULLI, DM

WEEKS, DE

机构：

[1] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261

[2] UNIV PITTSBURGH,DEPT COMP SCI,PITTSBURGH,PA 15261

来源：

HUMAN HEREDITY | 1995年 / 45卷 / 02期

关键词：

GENETIC LIKELIHOOD; LINKAGE ANALYSIS; PARALLEL COMPUTING; CRI-MAP;

D O I：

10.1159/000154268

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have developed a version of the CRI-MAP computer program for genetic likelihood computations that runs the FLIPS and ALL functions of CRI-MAP in parallel on a distributed network of workstations. The performance of CRI-MAP-PVM was assessed in several linkage analyses using the FLIPS option of CRI-MAP on a map of 85 microsatellite markers for human chromosome 1. These analyses showed excellent speedup and efficiency and low distribution overhead. In addition, we have adapted the MultiMap program for automated construction of linkage maps to use CRI-MAP-PVM. These improvements significantly reduce the time required to compare likelihoods of different marker orders. Thus, the construction of linkage maps can proceed in a more timely fashion, in keeping with recent advances in genotyping technology.

引用

页码：103 / 116

页数：14

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