CHARGE-TRANSFER CHROMATOGRAPHIC STUDY OF THE INTERACTION OF ANTICANCER DRUGS WITH ACETYL-BETA-CYCLODEXTRIN

被引：4

作者：

CSERHATI, T

机构：

[1] Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest, 1525

来源：

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1994年 / 349卷 / 10-11期

关键词：

D O I：

10.1007/BF00325652

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The interaction between 23 anticancer drugs and acetyl-beta-cyclodextrin (acetyl-beta-CD) was studied by reversed-phase charge-transfer thin-layer chromatography and the relative strength of interaction was calculated. Acetyl-beta-CD formed inclusion complexes with 16 compounds, the complex always being more hydrophilic than the uncomplexed drug. The inclusion forming capacity of drugs differed considerably according to their chemical structure. The significant linear correlation between the hydrophobicity and specific hydrophobic surface area of anticancer drugs indicated that they can be considered as a homologous series of compounds, however, their chemical structures are highly different.

引用

页码：751 / 755

页数：5

共 33 条

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