PRELIMINARY-REPORT ON ADRENAL-BRAIN TRANSPLANTATION FOR PARKINSONISM IN MAN

被引:12
作者
BAKAY, RAE
WATTS, RL
FREEMAN, A
IUVONE, PM
WATTS, N
GRAHAM, SD
机构
[1] EMORY UNIV, SCH MED, ATLANTA, GA 30322 USA
[2] VET ADM MED CTR, DEPT NEUROL, ATLANTA, GA USA
[3] VET ADM MED CTR, DEPT PHARMACOL, ATLANTA, GA USA
[4] VET ADM MED CTR, DEPT MED, ATLANTA, GA USA
[5] VET ADM MED CTR, DEPT SURG, DIV NEUROL SURG, ATLANTA, GA USA
关键词
Adrenal medulla; Cerebrospinal fluid; Homovanillic acid; Parkinson’s disease; Tissue transplantation; Tyrosine hydroxylase;
D O I
10.1159/000100228
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The attempt to restore lost neurological function through grafting of cate- cholaminergic tissue into the striatum is a dramatic new experimental treatment approach for parkinsonism. We have grafted autologous adrenal medullary tissue into the right caudate nucleus in 12 patients with advanced Parkinson’s disease (10 males, 2 females, mean age 53 years, mean Hoehn and Yahr stage ‘off medications 4.2) applying a transcortical technique similar to that of Madrazo as modified by Allen using right adrenalectomy performed via a flank approach. There have been no deaths, surgical complications, or serious postoperative morbidity. Modified Columbia Parkinson’s disease ratings of patients off all dopaminergic agents for 72 h revealed 22% improvement (p <0.01) 3-6 months postoperatively (n = 10) and 22% improvement (p <0.01) 7-12 months later (n = 9). Postoperative dyskinesias necessitated reduction of E-dopa by 11% and of carbidopa by 29%. Analysis of lumbar cerebrospinal fluid biogenic amine metabolites following a 4-day ‘drug holiday’ revealed that homovanillic acid increased to 159% of preoperative levels (p <0.01) 3-6 months (n = 9) and to 197% of preoperative levels (p <0.02) 7-12 months postoperatively (n = 5). We have observed a mild to moderate improvement persisting up to I year with this therapeutic approach, but further study is needed. © 1990 S. Karger AG, Basel.
引用
收藏
页码:312 / 323
页数:12
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