AUGMENTED IGG ANTIACETYLCHOLINE RECEPTOR RESPONSE FOLLOWING CHRONIC PENICILLAMINE ADMINISTRATION

被引：2

作者：

BEVER, CT

ASOFSKY, R

机构：

[1] UNIV TENNESSEE CTR HLTH SCI, DVAMC, RES SERV, MEMPHIS, TN 38163 USA

[2] UNIV TENNESSEE CTR HLTH SCI, DEPT NEUROL, MEMPHIS, TN 38163 USA

[3] UNIV MARYLAND, DVAMC, RES SERV, BALTIMORE, MD 21201 USA

[4] UNIV MARYLAND, DEPT NEUROL, BALTIMORE, MD 21201 USA

[5] NIAID, MICROBIAL IMMUN LAB, BETHESDA, MD 20892 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1991年 / 35卷 / 1-3期

关键词：

MYASTHENIA GRAVIS; ANTIACETYLCHOLINE RECEPTOR ANTIBODY; D-PENICILLAMINE;

D O I：

10.1016/0165-5728(91)90168-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A model Of D-penicillamine (DP) induced myasthenia gravis (MG) was developed in which the anti-acetylcholine receptor (anti-AChR) antibody response to AChR challenge was increased in mice chronically treated with DP. To investigate the mechanism of the DP induced increase, IgM and IgG anti-AChR responses to AChR challenge were studied. IgG responses were significantly greater in the DP treated mice than in the control group while IgM responses were not significantly different. This change appeared to be relatively specific for the AChR response because neither serum immunoglobulin levels nor the IgG response to a second antigen (purified protein derivative) were increased by DP treatment. These results suggest that a specific sensitization to AChR occurs during chronic DP treatment.

引用

页码：131 / 137

页数：7

共 41 条

[1] PENICILLAMINE-INDUCED MYASTHENIA-GRAVIS - EFFECTS OF PENICILLAMINE ON ACETYLCHOLINE-RECEPTOR [J].