THROMBOXANE BIOSYNTHESIS AND METABOLISM IN RELATION TO CARDIOVASCULAR RISK-FACTORS

被引：40

作者：

PATRONO, C

DAVI, G

CIABATTONI, G

机构：

[1] UNIV CHIETI G DANNUNZIO, SCH MED, DEPT HEMATOL, CHIETI, ITALY

[2] UNIV CATTOLICA SACRO CUORE, SCH MED, DEPT PHARMACOL, I-00168 ROME, ITALY

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/1050-1738(92)90039-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Enhanced platelet biosynthesis of thromboxane A2 is associated with several cardiovascular risk factors, as a consequence of a direct effect on platelet biochemistry and/or some form of endothelial dysfunction. Moreover, episodic increases in thromboxane biosynthesis occur in acute coronary and cerebral ischemic syndromes. Thromboxane-dependent platelet activation represents an important mechanism that amplifies the consequences of acute vascular lesions as well as those of longstanding metabolic or hemodynamic disturbances, and results in increased risk of vascular occlusive events.

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页码：15 / 20

页数：6

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