EFFICACY OF FIXED MINIDOSE WARFARIN PROPHYLAXIS IN TOTAL HIP-REPLACEMENT

被引:48
作者
FORDYCE, MJF [1 ]
BAKER, AS [1 ]
STADDON, GE [1 ]
机构
[1] WINFORD ORTHOPAED HOSP,BRISTOL,ENGLAND
关键词
DEEP-VEIN THROMBOSIS; LOW-DOSE HEPARIN; PREVENTION; FAILURE;
D O I
10.1136/bmj.303.6796.219
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective - To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement. Design - Prospective, randomised, double blind placebo controlled trial. Setting - Winford Orthopaedic Hospital, Bristol. Subjects - 148 patients having primary total hip replacement. Intervention - Warfarin 1 mg given daily for one week before and three weeks after surgery. Main outcome measure - Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method. Results - Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%). Conclusion - Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
引用
收藏
页码:219 / 220
页数:2
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