CELLULAR MECHANISMS OF ENTRAINMENT

被引:14
作者
COLWELL, CS [1 ]
KHALSA, SBS [1 ]
BLOCK, GD [1 ]
机构
[1] UNIV VIRGINIA,DEPT BIOL,GILMER HALL,CHARLOTTESVILLE,VA 22901
关键词
LIGHT; 5-HT; CIRCADIAN; APLYSIA; BULLA;
D O I
10.3109/07420529209064528
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This review summarizes our current understanding of the signal transduction cascade by which light causes phase shifts of the circadian oscillators found in the eye of Bulla and Aplysia. The isolated retina of these marine mollusks contains a circadian oscillator, a photoreceptor, and a light transduction pathway sufficient for entrainment. This preparation offers unique advantages for the cellular analysis of entrainment and the generation of circadian oscillations. There is evidence that similar cellular mechanisms may underlie mammalian and molluskan circadian oscillations. Thus, the models developed to explain entrainment in the molluskan retina are likely to have utility in exploring the mammalian suprachiasmatic nucleus.
引用
收藏
页码:163 / 179
页数:17
相关论文
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