AMYGDALA KINDLING INCREASED FEAR-RESPONSE, BUT DID NOT IMPAIR SPATIAL MEMORY IN RATS

被引：55

作者：

NIEMINEN, SA ^{[1
]}

SIRVIO, J ^{[1
]}

TEITTINEN, K ^{[1
]}

PITKANEN, A ^{[1
]}

AIRAKSINEN, MM ^{[1
]}

RIEKKINEN, P ^{[1
]}

机构：

[1] UNIV KUOPIO,DEPT NEUROL,SF-70211 KUOPIO,FINLAND

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 04期

关键词：

AMYGDALA KINDLING; ANXIETY; EMOTIONALITY; FEAR RESPONSE; MOTOR COORDINATION; OPEN FIELD; RAT; SPATIAL LEARNING;

D O I：

10.1016/0031-9384(92)90125-L

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The behavior effects of amygdala kindling, a model of experimental epilepsy in rats, are reported. The animals were stimulated twice a day until stage 5 (generalized clonic) seizures were obtained three times. Two weeks later the performance of the amygdala-kindled and sham-operated rats was tested in the open-field test, on the elevated plus maze, elevated bridges, and in the Morris water maze. The results show that amygdala kindling decreased exploratory and other motor activity in the open-field test. had anxiogenic effects on the elevated plus-maze, decreased boldness on the elevated bridges, but had a negligible affect in the spatial memory task. These results suggest that amygdala kindling affects the normal fear reaction of rats, a response that is known to be mediated through the amygdaloid pathways.

引用

页码：845 / 849

页数：5

共 35 条

[1] SPATIAL-LEARNING AND MEMORY PROCESSES - THE SEARCH FOR THEIR NEUROBIOLOGICAL MECHANISMS IN THE RAT [J].