INCREASE OF CENTRAL 5-HT(1B) BINDING-SITES FOLLOWING 5,7-DIHYDROXYTRYPTAMINE AXOTOMY IN THE ADULT-RAT

被引：42

作者：

MANRIQUE, C

SEGU, L

HERY, F

HERY, M

FAUDON, M

FRANCOISBELLAN, AM

机构：

[1] INSERM,U297,UNITE NEUROENDOCRINOL EXPTL,BLVD PIERRE DRAMARD,F-13916 MARSEILLE 20,FRANCE

[2] CNRS,NEUROBIOL LAB,MARSEILLE,FRANCE

来源：

BRAIN RESEARCH | 1993年 / 623卷 / 02期

关键词：

SEROTONIN 5-HT(1B) RECEPTOR; 5,7-DIHYDROXYTRYPTAMINE; UP-REGULATION; QUANTITATIVE AUTORADIOGRAPHY; HYPOTHALAMUS;

D O I：

10.1016/0006-8993(93)91452-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 mug free base) on 5-HT1B binding sites labeled with S-CM-G-[I-125]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surgery, an upregulation of 5-HT1B receptors in the entorhinal cortex and the dorsomedial and suprachiasmatic nuclei of the hypothalamus. The cellular localization of those 5-HT1B receptors exhibiting post-lesion plastic properties is discussed.

引用

页码：345 / 348

页数：4

共 21 条

[1]

BOSCHAERT U, UNPUB NEUROSCIENCE

[2] BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF SEROTONIN-ORTHO-CARBOXYMETHYLGLYCY1[125]IODOTYROSINAMIDE, A NEW RADIOIODINATED PROBE FOR 5-HT1B AND 5-HT1D BINDING-SITES [J].