RESTRICTED DISTRIBUTION OF MESSENGER-RNA PRODUCED FROM A SINGLE NUCLEUS IN HYBRID MYOTUBES

被引：64

作者：

RALSTON, E ^{[1
]}

HALL, ZW ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PHYSIOL, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF CELL BIOLOGY | 1992年 / 119卷 / 05期

关键词：

D O I：

10.1083/jcb.119.5.1063

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although the proteins encoded by a single nucleus in multinucleated myotubes have a wide range of distributions within the myofiber, little is known about the distributions of their mRNAs. We have used hybrid myotubes in which one or a few nuclei are derived from myoblasts that express nonmuscle proteins to investigate this question. We find that three different mRNAs, encoding proteins that are, respectively, nuclear, cytoplasmic, and targeted to the ER, have similar distributions within myotubes. Each is confined to an area within approximately 100 mum of the nucleus that expresses it.

引用

页码：1063 / 1068

页数：6

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