NITRILE OXIDES IN MEDICINAL CHEMISTRY .5. LIPASE PS-CATALYZED RESOLUTION OF A SET OF HETEROCYCLIC-DERIVATIVES

被引：22

作者：

CARREA, G ^{[1
]}

DEAMICI, M ^{[1
]}

DEMICHELI, C ^{[1
]}

LIVERANI, P ^{[1
]}

CARNIELLI, M ^{[1
]}

RIVA, S ^{[1
]}

机构：

[1] UNIV TRIESTE, DIPARTIMENTO SCI FARMACEUT, I-34127 TRIESTE, ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)80155-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lipase from Pseudomonas cepacia (lipase PS) catalyzed the hydrolysis of a series of butyrates of racemic primary alcohols carrying a DELTA2-isoxazoline or an isoxazolidin-3-one nucleus. Within this set of compounds, the enantiopreference of the catalyst can be accounted for by a rule recently proposed for lipase PS-catalyzed resolution of secondary alcohols. Nevertheless much work needs to be done in order to become predictive of the degree of enantioselectivity and of the relative reaction rates.

引用

页码：1063 / 1072

页数：10

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