Genetic analysis of a common oligogenic trait with quantitative correlates: Summary of GAW9 results

被引:28
作者
Blangero, J
机构
[1] Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas
关键词
statistical genetics; segregation analysis; linkage analysis;
D O I
10.1002/gepi.1370120628
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The statistical genetic analyses of a simulated data set for Genetic Analysis Workshop 9 Problem 2 are summarized. A diverse set of methods are evaluated with regard to the success with which they were able to determine the mode of inheritance and locate the genes underlying an oligogenically determined disease and four related quantitative traits. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:689 / 706
页数:18
相关论文
共 19 条
  • [1] AMOS CI, 1994, AM J HUM GENET, V54, P535
  • [2] USE OF ROBUST VARIANCE-COMPONENTS MODELS TO ANALYZE TRIGLYCERIDE DATA IN FAMILIES
    BEATY, TH
    SELF, SG
    LIANG, KY
    CONNOLLY, MA
    CHASE, GA
    KWITEROVICH, PO
    [J]. ANNALS OF HUMAN GENETICS, 1985, 49 (OCT) : 315 - 328
  • [3] BLANGERO J, 1993, HUM BIOL, V65, P941
  • [4] MULTIVARIATE SEGREGATION ANALYSIS USING THE MIXED MODEL
    BLANGERO, J
    KONIGSBERG, LW
    [J]. GENETIC EPIDEMIOLOGY, 1991, 8 (05) : 299 - 316
  • [5] BLANGERO J, 1990, AM J HUM GENET, V47, P414
  • [6] MULTIVARIATE GENETIC-ANALYSIS OF NEVUS MEASUREMENTS AND MELANOMA
    BLANGERO, J
    WILLIAMSBLANGERO, S
    KAMMERER, CM
    TOWNE, B
    KONIGSBERG, LW
    [J]. CYTOGENETICS AND CELL GENETICS, 1992, 59 (2-3): : 179 - 181
  • [7] REGRESSIVE LOGISTIC-MODELS FOR FAMILIAL DISEASE AND OTHER BINARY TRAITS
    BONNEY, GE
    [J]. BIOMETRICS, 1986, 42 (03) : 611 - 625
  • [8] BORECKI IB, 1990, AM J HUM GENET, V47, P542
  • [9] ROBUST GENETIC-LINKAGE ANALYSIS BASED ON A SCORE TEST OF HOMOGENEITY - THE WEIGHTED PAIRWISE CORRELATION STATISTIC
    COMMENGES, D
    [J]. GENETIC EPIDEMIOLOGY, 1994, 11 (02) : 189 - 200
  • [10] SEARCH FOR FASTER METHODS OF FITTING THE REGRESSIVE MODELS TO QUANTITATIVE TRAITS
    DEMENAIS, FM
    MURIGANDE, C
    BONNEY, GE
    [J]. GENETIC EPIDEMIOLOGY, 1990, 7 (05) : 319 - 334