BIOCHEMICAL-CHARACTERIZATION AND MEMBRANE EXPRESSION OF AN ANTIGEN SHARED BY ACTIVATED AND NEOPLASTIC-CELLS OF NEUROECTODERMAL ORIGIN

被引：3

作者：

BALDISSARRO, I

MARRONI, P

SMILOVICH, D

CAPRA, MC

MARIMPIETRI, D

MONTALTI, S

SEVERI, AB

GROSSI, CE

COSULICH, ME

机构：

[1] CBA,IST SCI TUMORI,UNITA MONOCLONALI,I-16132 GENOA,ITALY

[2] UNIV GENOA,IST CHIM BIOL,GENOA,ITALY

[3] UNIV GENOA,IST ANAT UMANA,GENOA,ITALY

[4] UNIV PAVIA,DIPARTMENTO BIOCHIM,PAVIA,ITALY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 57卷 / 1-2期

关键词：

MONOCLONAL ANTIBODIES; SMALL CELL LUNG CARCINOMA; RETINOBLASTOMA; BRAIN TUMORS; ACTIVATION;

D O I：

10.1016/0165-5728(94)00157-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The reactivity of a mAb (M16) raised against a small cell lung carcinoma line is described. M16 identifies a surface antigen expressed on cells of neuroectodermal origin following activation, as well as neoplastic transformation. M16 antigen expression is increased on retinoblastoma and neuroblastoma cell lines upon 'in vitro' stimulation and it is induced 'in vivo' on glial cells activated following brain injury. Furthermore, glial tumors show levels of M16 molecule expression increasing with the degree of malignancy, and in a retinoblastoma cell line, the expression of M16 was inversely related to the level of HLA-Class I and N-CAM antigens. The M16 antigen may represent a marker of both activation and neoplastic progression for neuroectodermal cells.

引用

页码：17 / 26

页数：10

共 26 条

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