DETERMINATION OF THE MINIMUM DOSE OF LACTOSE DRUG CARRIER THAT CAN BE SENSED DURING INHALATION

被引：4

作者：

HIGHAM, MA ^{[1
]}

SHARARA, AM ^{[1
]}

MAGEE, RP ^{[1
]}

IND, PW ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED,DIV RESP,LONDON W12 0NN,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1995年 / 40卷 / 03期

关键词：

LACTOSE; INHALATION; SENSATION;

D O I：

10.1111/j.1365-2125.1995.tb05786.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lactose is commonly used as a carrier for inhaled drugs. Twenty healthy volunteers without respiratory: symptoms inhaled seven different doses of. lactose and a placebo (empty) dose through the four place Diskhaler(R) device, in order to determine the lowest dose that could be reliably sensed. The minimum dose for which all subjects reported taste or feel sensations was 10 mg. This has implications regarding the amount of carrier used in future drug delivery systems.

引用

页码：281 / 282

页数：2

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