EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR-ALPHA ACTIONS ON THE GUT

被引：30

作者：

GOODLAD, RA

WRIGHT, NA

机构：

[1] Histopathology Unit, Imperial Cancer Research Fund, London

[2] Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1995年 / 7卷 / 10期

关键词：

EPIDERMAL GROWTH FACTOR (EGF); TRANSFORMING GROWTH FACTOR-ALPHA; EGF RECEPTOR; GASTROINTESTINAL GROWTH; CYTOPROTECTION;

D O I：

10.1097/00042737-199510000-00004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) are part of a large family of ligands that bind to the epidermal growth factor receptor. While the precise role of these ligands is still unclear, there is little doubt that they play an important role in the development and maintenance of gastrointestinal epithelial continuity. The main ligand for the intestinal EGF receptor (EgFR) may in fact be TGF-alpha, and there is evidence that EGF itself may act as a surveillance factor in adults, only having an effect if the mucosa is damaged.

引用

页码：928 / 932

页数：5

共 29 条

[1]

Sporn M.B., Roberts A.B., Peptide growth factors are multifunctional, Nature, 332, pp. 217-219, (1988)

[2]

Sandweiss D.J., Enterogastrone, anthelone and urogastrone, Gastroenterology, 5, pp. 404-415, (1945)

[3]

Gregory H., Isolation and structure of urogastrone and its relation to epidermal growth factor, Nature, 257, pp. 325-327, (1975)

[4]

Rackoff P.J., Zdon M.J., Tyshkov M., Modlin I.M., Epidermal growth factor (EGF) inhibits both intrinsic factor secretion and acid secretion in histamine-stimulated isolated gastric glands, Regul Pept, 21, pp. 279-287, (1988)

[5]

Garner A., Therapeutic potential of growth factors and their nantagonists, Yale J Biol Med, 65, pp. 715-723, (1992)

[6]

Merchant J.L., Demediuk B., Brand S.J., A GC-rich element confers epidermal growth factor responsiveness to transcription from the gastrin promoter, Mol Cell Biol, 11, pp. 2686-2696, (1991)

[7]

Chew C.S., Nakamura K., Petropoulos A.C., Multiple actions of epidermal growth-factor and TGF-a on rabbit gastric parietal-cell function, Am I Physiol, 30, pp. 818-826, (1994)

[8]

Olsen P.S., Poulsen S.S., Therkelsen K., Nexo E., Effect of sialo-adenectomy and synthetic human urogastrone on healing of chronic gastric ulcers in rats, Gut, 27, pp. 1443-1449, (1986)

[9]

Ohmura E., Emoto N., Tsushima T., Watanabe S., Takeuchi T., Kawamura M., Et al., Salivary immunoreactive human epidermal growth factor (IR-hEGF) in patients with peptic ulcer disease, Hepatogastroenterology, 34, pp. 160-163, (1987)

[10]

Procaccino F., Reinshagen M., Hoffmann P., Zeeh J.M., Lakshmanan J., McRoberts J.A., Et al., Protective effect of epidermal growth factor in an experimental model of colitis in rats, Gastroenterology, 107, pp. 12-17, (1994)

← 1 2 3 →