EFFECT OF ADRENERGIC BLOCKING AGENTS ON PLASMA GLUCOSE IN RABBITS

被引：10

作者：

CALVEY, TN

SUMMERILL, RA

机构：

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1968年 / 4卷 / 01期

关键词：

Blood-sugar; Insulin hypoglycaemia; Phentolamine; Propranolol;

D O I：

10.1016/0014-2999(68)90008-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of phentolamine and propranolol on blood sugar was studied in normal and in hypoglycaemic rabbits. Phentolamine increased resting plasma glucose, and reduced the hypoglycaemic response to insulin. The percentage change in blood sugar induced by phentolamine was diminished during insulin hypoglycaemia. In contrast, propranolol decreased resting plasma glucose, increased the hypoglycaemic response to insulin and delayed the restoration of normal blood sugar levels. The relative effect of propranolol on plasma glucose was increased during hypoglycaemia. It was concluded that the effects of phentolamine on blood sugar were unrelated to alpha-adrenergic blockage. However, the effects of propranolol were consistent with antagonism of the beta-effects of circulating adrenaline. © 1968.

引用

页码：47 / +

页数：1

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