MECHANISM STUDIES ON TUSSIVE ACTION OF 1,1-DIMETHYL-4-PHENYLPIPERAZINIUM IODIDE

被引：5

作者：

SANZARI, NP

EMELE, JF

FAINMAN, FB

机构：

[1] Department of Pharmacology, Consumer Products Research Division, Warner-Lambert Research Institute, Morris Plains, NJ

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 8卷 / 02期

关键词：

Chemoreceptor; Cough reflex; Dimethylphenylpiperazinium iodide;

D O I：

10.1016/0014-2999(69)90075-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mechanism of the tussive action of 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) was investigated in terms of the sensory, central coordinating and motor components of the cough reflex. DMPP was found to evoke cough by an action on the afferent limb involving chemoreceptors of the carotid and possibly pulmonary areas. The tussive response to DMPP appeared to be unrelated to its classical action on autonomic ganglia. © 1969.

引用

页码：185 / &

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