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STUDIES OF INEFFECTIVE ERYTHROPOIESIS AND PERIPHERAL HEMOLYSIS IN CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE-II

被引：24
作者：
BAROSI, G
CAZZOLA, M
STEFANELLI, M
ASCARI, E
机构：
[1] UNIV PAVIA,IST PATOL MED 1,MED CLIN 1,I-27100 PAVIA,ITALY
[2] UNIV PAVIA,IST INFORMAT & SISTEMT,I-27100 PAVIA,ITALY
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 02期
关键词：
D O I：
10.1111/j.1365-2141.1979.tb03747.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Summary. Erythrokinetic parameters were estimated in six patients suffering from congenital dyserythropoietic anaemia type II (CDA II) by means of a mathematical model of iron kinetics. A wide variation in effectiveness of erythroid activity was observed, and a significant negative correlation was found between ineffective erythropoiesis and peripheral haemolysis. In four patients with prominent peripheral haemolysis, splenectomy was carried out. Marked improvement in their clinical condition and in haemoglobin level resulted. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：243 / 250
页数：8
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