INVESTIGATION OF PIROXICAM POLYMORPHISM

被引：67

作者：

VRECER, F

SRCIC, S

SMIDKORBAR, J

机构：

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 68卷 / 1-3期

关键词：

PIROXICAM; POLYMORPHISM; DSC; INFRARED SPECTROSCOPY; CRYSTALLIZATION; MELT COOLING;

D O I：

10.1016/0378-5173(91)90124-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The polymorphism of piroxicam has been discussed by many authors, but it is still uncertain in how many polymorphic and pseudopolymorphic modifications it can exist. The results of DSC and IR analyses confirm that simple crystallization from different solvents yields modifications designated as I and II and monohydrate. Depending on the cooling rate of the piroxicam melt, amorphous or metastable polymorphic forms referred to as III and IV were obtained.

引用

页码：35 / 41

页数：7

共 9 条

[1] PHARMACEUTICAL APPLICATIONS OF POLYMORPHISM [J].