RENIN-ACTIVATION BY KALLIKREIN - EVIDENCE FOR ALKALINE-ACTIVATION OF PLASMA-RENIN

被引：9

作者：

HUMMERICH, W

FELTKAMP, H

KONRADS, A

AHLMANN, P

BORNHOFEN, H

机构：

[1] Department of Internal Medicine II, University of Cologne

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 9卷 / 06期

关键词：

kallikrein; Renin; renin‐activation; renin‐precursors;

D O I：

10.1111/j.1365-2362.1979.tb00911.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8·2. ‘Endogenous’ activation of plasma renin can be seen by incubation of plasmas at the same pH. Both ‘endogenous’ alkaline‐ and kallikrein‐activation of plasma renin can be inhibited by aprotinin. Both, kallikrein‐ and ‘endogenous’ alkaline activation of plasma renin are significantly correlated to cryo‐ and acid‐activation. We suggest that kallikrein‐ and ‘endogenous’ alkaline‐activation come close to the in vivo activation process. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：447 / 449

页数：3

共 16 条

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[2]

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[8]

HUMMERICH W, 1978, RADIOIMMUNOASSAY REN, P116

[9]

Leckie B J, 1977, Adv Exp Med Biol, V95, P249

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CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 55 :S133-S134

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