PHARMACOKINETIC INTERACTION OF PROPOFOL AND FENTANYL - SINGLE BOLUS INJECTION STUDY

被引:29
作者
GILL, SS
WRIGHT, EM
REILLY, CS
机构
[1] Department of Anaesthesia, University of Sheffield, Sheffield S10 2RX, Beech Hill Road
关键词
Anaesthetics; intravenous:; propofol; Analgesics: fentanyl; Pharmacokinetics;
D O I
10.1093/bja/65.6.760
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The effect of pretreatment with fentanyl on the pharmacokinetics of a single bolus of propofol was studied in 17 female patients (mean age 35 yr), ASA grade l. Eight patients received fentanyl 1.5 μg kg-1 5 min before induction of anaesthesia. In all patients anaesthesia was induced with propofol 2.5 mg kg-1 and maintained with halothane and nitrous oxide in oxygen. Pretreatment with fentanyl resulted in prolonged apnoea in all eight patients compared with three of nine patients in the control group. The pharmacokinetic values for propofol were described by a three-compartment mammillary model with rapid distribution phases (Tα mean (SEM) 3.1 (2.0) min and β 44 (9.1) min) and a slower final phase of γ ≪520 (96) min. The clearance of propofol was rapid (mean 1.6 (0.24) litre min-1). Propofol was distributed initially into a relatively large central compartment (mean 23.7 (6.6) litre) and was extensively redistributed (mean Vss 593 (157) litre). There was no difference in the pharmacokinetic profile of propofol between the two groups. © 1990 Copyright: 1990 British Journal of Anaesthesia.
引用
收藏
页码:760 / 765
页数:6
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