SYNTHESIS OF ANTITUMOR ANSAMYCINS .2. A FORMAL SYNTHESIS OF (+/-)-MACBECIN-I

被引：16

作者：

COUTTS, SJ ^{[1
]}

KALLMERTEN, J ^{[1
]}

机构：

[1] SYRACUSE UNIV,DEPT CHEM,SYRACUSE,NY 13244

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)97607-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin. © 1990.

引用

页码：4305 / 4308

页数：4

共 18 条

[1] THE TOTAL SYNTHESIS OF (+)-MACBECIN-I
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[2] ENANTIOSPECIFIC SYNTHESIS OF THE C-9 TO C-18 FRAGMENT OF MACBECIN-I AND MACBECIN-II
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[3] TOTAL SYNTHESIS OF (+)-MACBECIN-I
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CASTRO, JL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (01): : 47 - 65
[4] ENANTIOSELECTIVE SYNTHESIS OF THE C1,6-C21,16 SEGMENT OF MACBECIN-I AND MACBECIN-II
BAKER, R
CASTRO, JL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (01): : 190 - 192
[5] A NEW APPROACH TO THE TOTAL SYNTHESIS OF PSEUDOMONIC ACID-C
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[6] FURTHER OBSERVATIONS ON THE LEWIS ACID-CATALYZED BENZYLIC HYDROPEROXIDE REARRANGEMENT - USE OF A BORON-TRIFLUORIDE HYDROGEN-PEROXIDE PREFORMED, AGED REAGENT
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[7] BENZYLIC HYDROPEROXIDE REARRANGEMENT - OBSERVATIONS ON A VIABLE AND CONVENIENT ALTERNATIVE TO THE BAEYER-VILLIGER REARRANGEMENT
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COLEMAN, RS
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (26) : 5436 - 5439
[8] COUTTS SJ, 1990, TETRAHEDRON LETT, V31, P4301
[9] EVANS DA, 1984, 27TH P RA WELCH F C, P13
[10] THE REGIOSPECIFIC SYNTHESIS OF THE A-RING AND B-RING OF PHOMAZARIN
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[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1987, 24 (06) : 1649 - 1652

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