PROTECTIVE VALUE OF ELEVATED LEVELS OF GAMMA-INTERFERON IN SERUM AGAINST EXOERYTHROCYTIC STAGES OF PLASMODIUM-FALCIPARUM

被引:32
作者
DELORON, P
CHOUGNET, C
LEPERS, JP
TALLET, S
COULANGES, P
机构
[1] HOP CLAUDE BERNARD, INST MED & EPIDEMIOL AFRICAINES, F-75019 PARIS, FRANCE
[2] UNIV PARIS 05, BIOL PARASITAIRE LAB, F-75005 PARIS, FRANCE
[3] HOP BICHAT, IMMUNOL CELLULAIRE LAB, F-75877 PARIS 18, FRANCE
[4] INST PASTEUR MADAGASCAR, UNITE RECH PALUDISME, ANTANANARIVO, MADAGASCAR
关键词
D O I
10.1128/JCM.29.9.1757-1760.1991
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In vitro experiments suggested that gamma interferon, CD8+ T cells, and anticircumsporozoite antibodies inhibited the exoerythrocytic stages of malaria parasites. To assess the role played in vivo by these factors, we conducted a prospective study in Madagascar. Forty individuals with a negative blood smear were followed for 8 weeks to detect the appearance of parasites in blood. Nineteen subjects remained negative for malaria, whereas 21 individuals became positive during follow-up. Among these, seven presented with blood parasites within the first 2 weeks and were excluded, as they probably were infected by sporozoites at enrollment. When measured at enrollment, antibodies to the synthetic peptide (NANP)5, lymphocyte proliferation with (NANP)5, and various lymphocytes subsets were similar among individuals that later presented with a Plasmodium falciparum blood infection or were not infected. Conversely, the level of gamma interferon in serum was higher in individuals that did not present with a P. falciparum infection during follow-up. These data suggest that gamma interferon may inhibit the malaria exoerythrocytic stages of development under in vivo conditions, as it does in vitro.
引用
收藏
页码:1757 / 1760
页数:4
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