MEASUREMENT OF PARTICLE-SIZE CHARACTERISTICS OF METERED DOSE INHALER (MDI) AEROSOLS

被引：26

作者：

DOLOVICH, M

机构：

[1] Department of Medicine, St. Joseph's Hospital, McMaster University, Hamilton, Ontario

来源：

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG | 1991年 / 4卷 / 03期

关键词：

PARTICLE SIZE; CASCADE IMPACTION; LIGHT SCATTERING; METERED-DOSE INHALERS;

D O I：

10.1089/jam.1991.4.251

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Measurement of the aerodynamic size of an aerosol allows a prediction of its deposition efficiency and behaviour in the lung. The dynamics of volatile or pressurized (MDI) aerosols presents problems not encountered in the characterization of solid or liquid particles alone. For example, the data obtained in real-time sampling as opposed to measuring an aged aerosol provide a truer representation of circumstances during actual clinical use, yet this may be difficult to achieve due to propellent evaporation. A number of particle sizing systems have been developed based upon light scattering techniques and aerodynamic principles. Each method has its limitations; in general, they successfully measure the aerodynamic size distributions of MDI aerosols. Cascade impactors, the “gold standard” of the industry have the advantage that they allow analysis of drug mass as well as other tracers within the aerosol, but the process as a whole is labour intensive, with limited resolution. Highly automated laser-based systems developed over the past 10 years measure the surface characteristics of the aerosol rather than the direct measurement of mass. Because of different values obtained from various sizing systems, it is suggested that all MDI drugs be sized using cascade impactors but that parallel data be obtained using an alternative sizing system. © 1991, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：251 / 263

页数：13

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