MADUROPEPTIN, A COMPLEX OF NEW MACROMOLECULAR ANTITUMOR ANTIBIOTICS

被引：55

作者：

HANADA, M ^{[1
]}

OHKUMA, H ^{[1
]}

YONEMOTO, T ^{[1
]}

TOMITA, K ^{[1
]}

OHBAYASHI, M ^{[1
]}

KAMEI, H ^{[1
]}

MIYAKI, T ^{[1
]}

KONISHI, M ^{[1
]}

KAWAGUCHI, H ^{[1
]}

FORENZA, S ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB,PHARMACEUT RES INST,WALLINGFORD,CT 06492

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 04期

关键词：

D O I：

10.7164/antibiotics.44.403

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.

引用

页码：403 / 414

页数：12

共 16 条

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