MODIFICATION OF APOMORPHINE-INDUCED BEHAVIOR FOLLOWING CHRONIC SWIM EXERCISE IN RATS
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DEY, S
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BANARAS HINDU UNIV,INST MED SCI,DEPT KAYACHIKITSA,VARANASI 221005,UTTAR PRADESH,INDIABANARAS HINDU UNIV,INST MED SCI,DEPT KAYACHIKITSA,VARANASI 221005,UTTAR PRADESH,INDIA
DEY, S
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SINGH, RH
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[1] BANARAS HINDU UNIV,INST MED SCI,DEPT KAYACHIKITSA,VARANASI 221005,UTTAR PRADESH,INDIA
FOUR week swim exercise schedule (45 min day-1, 6 days each week) in rats led to a significant adaptive change in functional responsiveness of dopamine receptors (auto-receptors) in the nigrostriatal and mesolimbic system that was evident from the modification of behavioural responses elicited by a low dose of apomorphine, a direct acting dopamine receptor agonist. Thus, a remarkable increase in yawning response, development of full blown stereotypy, as well as profound attenuation of locomotory and hypothermic response was observed in exercise-trained rats as compared with the non-exercise group (control), following intraperitoneal administration of 0.3 mg kg-1 of apomorphine.