SYNTHESIS OF OLIGOSACCHARIDES USING GLYCOSYLTRANSFERASES

被引：5

作者：

ICHIKAWA, Y ^{[1
]}

LOOK, GC ^{[1
]}

WONG, CH ^{[1
]}

KAJIMOTO, T ^{[1
]}

机构：

[1] INST PHYS & CHEM RES, FRONTIER RES SYST, WAKO, SAITAMA 351, JAPAN

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1992年 / 50卷 / 05期

关键词：

SIALYLTRANSFERASE; GALACTOSYLTRANSFERASE; SIALYL LEWIS X; CMP-N-ACETYLNEURAMINIC ACID; UDP-GALACTOSE; GDP-FUCOSE; OLIGOSACCHARIDE;

D O I：

10.5059/yukigoseikyokaishi.50.441

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Development of cloning techniques have made several glycosyltransferases available for organic chemists. Enzymatic synthesis of oligosaccharides using glycosyltransferases show high regio- and stereospecific glycosidic bond formations without protecting groups of hydroxyl groups. In this review, we describe recent developments in oligosaccharide synthesis employing sialyl-, galactosyl- and fucosyltransferase, which are necessary for the synthesis of sialyl Lewis X tetrasaccharide. Application of in situ cofactor regeneration systems avoids the tedious separate preparation of sugar nucleotide, and inhibition caused by the released nucleoside mono- or diphosphates.

引用

页码：441 / 450

页数：10

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