CARCINOMA AND DNA ANEUPLOIDY IN CROHNS COLITIS - A HISTOLOGICAL AND FLOW CYTOMETRIC STUDY

被引:20
作者
LOFBERG, R
BROSTROM, O
KARLEN, P
OST, A
TRIBUKAIT, B
机构
[1] KAROLINSKA INST, DEPT PATHOL, S-10401 STOCKHOLM 60, SWEDEN
[2] KAROLINSKA INST, DEPT MED RADIOBIOL, S-10401 STOCKHOLM 60, SWEDEN
[3] SODER SJUKHUSET, GASTROENTEROL UNIT, STOCKHOLM, SWEDEN
[4] KAROLINSKA HOSP, S-10401 STOCKHOLM 60, SWEDEN
关键词
D O I
10.1136/gut.32.8.900
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Twenty four patients with longstanding colonic Crohn's disease were examined prospectively with colonoscopy and multiple biopsy sampling in order to detect histological dysplasia or abnormal aneuploid DNA content, or both. Biopsy specimens were taken from 10 predetermined locations in the colon and rectum. No patient had definite dysplasia but three displayed DNA aneuploidy (12.5%), and one of these subsequently developed a carcinoma (Dukes' C at operation) in the ascending colon. No concomitant dysplasia was detected but the carcinoma as well as other parts of the mucosa were DNA aneuploid. It is concluded that dysplasia is rare in patients with Crohn's colitis, but findings of DNA aneuploidy warrant vigilance in follow up as this may indicate impending carcinoma. Further prospective studies are needed before the predictive value of DNA aneuploidy can be determined and before general recommendations of colonoscopic surveillance, as in long-standing ulcerative colitis, can be made.
引用
收藏
页码:900 / 904
页数:5
相关论文
共 27 条
  • [1] CRAFT CF, 1981, GASTROENTEROLOGY, V80, P578
  • [2] LONG-TERM FOLLOW-UP OF PATIENTS WITH CROHNS-DISEASE - RELATIONSHIP BETWEEN THE CLINICAL-PATTERN AND PROGNOSIS
    FARMER, RG
    WHELAN, G
    FAZIO, VW
    [J]. GASTROENTEROLOGY, 1985, 88 (06) : 1818 - 1825
  • [3] INTESTINAL CANCER IN PATIENTS WITH CROHNS-DISEASE - A POPULATION STUDY IN CENTRAL ISRAEL
    FIREMAN, Z
    GROSSMAN, A
    LILOS, P
    HACOHEN, D
    BARMEIR, S
    ROZEN, P
    GILAT, T
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1989, 24 (03) : 346 - 350
  • [4] EPIDEMIOLOGIC ASPECTS OF CROHNS-DISEASE - A POPULATION BASED STUDY IN OLMSTED COUNTY, MINNESOTA, 1943-1982
    GOLLOP, JH
    PHILLIPS, SF
    MELTON, LJ
    ZINSMEISTER, AR
    [J]. GUT, 1988, 29 (01) : 49 - 56
  • [5] GREENSTEIN AJ, 1981, CANCER, V48, P2742, DOI 10.1002/1097-0142(19811215)48:12<2742::AID-CNCR2820481231>3.0.CO
  • [6] 2-P
  • [7] COLORECTAL-CANCER IN ULCERATIVE-COLITIS - A COHORT STUDY OF PRIMARY REFERRALS FROM 3 CENTERS
    GYDE, SN
    PRIOR, P
    ALLAN, RN
    STEVENS, A
    JEWELL, DP
    TRUELOVE, SC
    LOFBERG, R
    BROSTROM, O
    HELLERS, G
    [J]. GUT, 1988, 29 (02) : 206 - 217
  • [8] MALIGNANCY IN CROHNS-DISEASE
    GYDE, SN
    PRIOR, P
    MACARTNEY, JC
    THOMPSON, H
    WATERHOUSE, JAH
    ALLAN, RN
    [J]. GUT, 1980, 21 (12) : 1024 - 1029
  • [9] COLORECTAL-CARCINOMA IN PATIENTS WITH CROHNS-DISEASE
    HAMILTON, SR
    [J]. GASTROENTEROLOGY, 1985, 89 (02) : 398 - 407
  • [10] HAMMARBERG C, 1984, CANCER, V53, P291, DOI 10.1002/1097-0142(19840115)53:2<291::AID-CNCR2820530218>3.0.CO